1-Bromo-3-chloropropane, [Trimethylene bromochloride]
1-Bromo-3-chloropropane
CAS: 109-70-6
Molecular Formula: C3H6BrCl
1-Bromo-3-chloropropane, [Trimethylene bromochloride] - Names and Identifiers
1-Bromo-3-chloropropane, [Trimethylene bromochloride] - Physico-chemical Properties
| Molecular Formula | C3H6BrCl |
| Molar Mass | 157.44 |
| Density | 1.592 g/mL at 25 °C (lit.) |
| Melting Point | -59 °C |
| Boling Point | 144-145 °C (lit.) |
| Flash Point | 81 °C |
| Water Solubility | insoluble |
| Solubility | 2.24g/l insoluble |
| Vapor Presure | 7.5 hPa (20 °C) |
| Appearance | liquid |
| Color | Clear liquid |
| BRN | 605278 |
| Storage Condition | room temp |
| Explosive Limit | 3.2-8.6%(V) |
| Refractive Index | n20/D 1.486(lit.) |
| Physical and Chemical Properties | Density 1.592 melting point -59°C boiling point 142-145°C refractive index 1.485-1.487 flash point 81°C water-soluble insoluble |
| Use | Used as pharmaceutical intermediates, mainly used in the synthesis of chlorpromazine, trifluoperazine, perphenazine, clomipramine, yantongjing, doxepin hydrochloride, telden and other products |
1-Bromo-3-chloropropane, [Trimethylene bromochloride] - Risk and Safety
| Hazard Symbols | Xn - Harmful |
| Risk Codes | R10 - Flammable R22 - Harmful if swallowed R36/37/38 - Irritating to eyes, respiratory system and skin. R20/21/22 - Harmful by inhalation, in contact with skin and if swallowed. R20/22 - Harmful by inhalation and if swallowed. R68 - Possible risk of irreversible effects R52/53 - Harmful to aquatic organisms, may cause long-term adverse effects in the aquatic environment. R37 - Irritating to the respiratory system |
| Safety Description | S16 - Keep away from sources of ignition. S45 - In case of accident or if you feel unwell, seek medical advice immediately (show the label whenever possible.) S36/37/39 - Wear suitable protective clothing, gloves and eye/face protection. S26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. |
| UN IDs | UN 2688 6.1/PG 3 |
| WGK Germany | 3 |
| RTECS | TX4113000 |
| TSCA | Yes |
| HS Code | 29034980 |
| Hazard Class | 6.1 |
| Packing Group | III |
| Toxicity | LD50 orally in Rabbit: 1100 - 1200 mg/kg LD50 dermal Rat > 2000 mg/kg |
1-Bromo-3-chloropropane, [Trimethylene bromochloride] - Upstream Downstream Industry
| Raw Materials | Hydrobromic acid Hydrobromic acid |
| Downstream Products | chloropromazine hydrochloride perphenazine |
1-Bromo-3-chloropropane, [Trimethylene bromochloride] - Nature
Open Data Verified Data
colorless liquid. Relative density 1. 592(20 ℃), boiling point 142~143 ℃. Refractive index 1.4851. Insoluble in water, soluble in ethanol, ether and chloroform.
Last Update：2024-01-02 23:10:35
1-Bromo-3-chloropropane, [Trimethylene bromochloride] - Preparation Method
Open Data Verified Data
obtained by the addition of a-chloropropene and hydrogen bromide.
Last Update：2022-01-01 10:14:35
1-Bromo-3-chloropropane, [Trimethylene bromochloride] - Use
Open Data Verified Data
used in the synthesis of medicine and inflammatory pain, fluphenazine, trifluoperazine, etc., also used in other organic synthesis.
Last Update：2022-01-01 10:14:35
1-Bromo-3-chloropropane, [Trimethylene bromochloride] - Safety
Open Data Verified Data
- accidental ingestion, skin contact or inhalation of vapor is harmful. More strongly irritate the skin, eyes and mucous membranes. The operator must wear full-body protective clothing.
- 250kg iron drum packing or glass bottle outer wooden box lining bedding. Store in a cool, ventilated warehouse; With acids, edible raw materials Isolation of the storage and transportation.
Last Update：2022-01-01 10:14:35
1-Bromo-3-chloropropane, [Trimethylene bromochloride] - Reference Information
| (IARC) carcinogen classification | 2B (Vol. 125) |
| NIST chemical information | information provided by: webbook.nist.gov (external link) |
| EPA chemical substance information | information provided by: ofmpeb.epa.gov (external link) |
| Use | used in the synthesis of medicine, inflammation and analgesia, fluphenazine, trifluoperazine, etc., also used in other organic synthesis. It is used for the synthesis of medicine, inflammation and analgesia, fluphenazine, trifluoperazine, etc. It is also used for other organic synthesis. Used as pharmaceutical intermediates, mainly for chlorpromazine, trifluoperazine, perphenazine, clomipramine, yantongjing, doxepin hydrochloride, synthesis of telden and other products for organic synthesis and pharmaceutical industry for chlorpromazine, gemfibrozil, trifluoperazine, perphenazine, mepromazine and other phenothiazines, inflammatory diseases, ibendin, telden, doxepin hydrochloride, vertigo, clindamycin, pentoxifylline, etc. In addition, it is also widely used in the synthesis of ciprofloxacin, an intermediate of ciprofloxacin. used in organic synthesis and pharmaceutical industry |
| production method | from the addition of α-chloropropene and hydrogen bromide, the α-chloropropene is sucked into the bromination tank, and a small amount of benzoyl peroxide is added, then the hydrogen bromide is introduced into the bottom of the tank, and the reaction temperature is controlled at 18 ° C. When the relative density is above 1.5, it is the end point. The product is washed with water and alkali (2% sodium hydroxide), then washed with water, the water layer is separated, dehydrated with anhydrous calcium chloride for 24h, and fractionated by regular pressure, and the low boiling substance below 130 ℃ is separated, then, distillation was performed under reduced pressure to collect a fraction above 70 ° C. (21.3kPa) to obtain a finished product. The hydrogen bromide used in the production is produced in the following way: hydrobromic acid is added to sodium bromide, the temperature is raised to 60 ° C. And sulfuric acid is added dropwise, and the reaction is maintained at 80-90 ° C. To give off hydrogen bromide gas. |
| category | toxic substances |
| toxicity grade | poisoning |
| Acute toxicity | oral-rat LD50: 930 mg/kg; Oral-mouse LD50:1290 mg/kg |
| flammability hazard characteristics | open flame flammable; Reaction with oxidant; Hyperthermic decomposition and exposure to acid release toxic chlorine, bromide gas |
| storage and transportation characteristics | The warehouse is ventilated and dried at low temperature, separate storage of food additives |
| fire extinguishing agent | water, foam, carbon dioxide, sand |
| Occupational Standard | SEL 3 mg/m3 |
| toxic substance data | information provided by: pubchem.ncbi.nlm.nih.gov (external link) |
Last Update：2024-04-09 20:52:54
![1-Bromo-3-chloropropane, [Trimethylene bromochloride]](http://res.chembk.com/assets/str/2d/1/10/109-70-6.png)
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View History
1-Bromo-3-chloropropane, [Trimethylene bromochloride]
水杨酸与甲醛及2-甲酚的聚合物
Perfluorohexanoic acid (potassium salt)
[2H7]-3-甲基马尿酸
DIMETHYL[3-OXO-3-(2-THIENYL)PROPYL]AMMONIUM BROMIDE
BAS 08302046
5-BROMO-2-[[[(3-NITROBENZOYL)AMINO]THIOXOMETHYL]AMINO]-BENZOIC ACID
水杨酸与甲醛及2-甲酚的聚合物
Perfluorohexanoic acid (potassium salt)
[2H7]-3-甲基马尿酸
DIMETHYL[3-OXO-3-(2-THIENYL)PROPYL]AMMONIUM BROMIDE
BAS 08302046
5-BROMO-2-[[[(3-NITROBENZOYL)AMINO]THIOXOMETHYL]AMINO]-BENZOIC ACID
Raw Materials for 1-Bromo-3-chloropropane, [Trimethylene bromochloride]
Downstream Products for 1-Bromo-3-chloropropane, [Trimethylene bromochloride]